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. 1975 May;27(3):287-91.

Tay-Sachs disease: high gene frequency in a non-Jewish population

T E Kelly  1 , G A Chase, M M Kaback, K Kumor, V A McKusick
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Tay-Sachs disease: high gene frequency in a non-Jewish population

T E Kelly et al. Am J Hum Genet. 1975 May.

Abstract

A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews.

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References

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