Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 May;27(3):365-84.

Analysis of family resemblance. IV. Operational characteristics of segregation analysis

C J MacLean  1 , N E Morton, R Lew
Affiliations

Analysis of family resemblance. IV. Operational characteristics of segregation analysis

C J MacLean et al. Am J Hum Genet. 1975 May.

Abstract

In simulated data, segregation analysis of quantitative traits was found to be powerful for resolving a major locus from polygenic and cultural inheritance. It is reasonably robust against a variety of deviations from the model if and only if a major locus, polygenic heritability, and environment common to sibs are simultaneously included in the model, and heterogeneity tests among mating types are performed. Most of the information in quantitative data about a major locus is lost when reduced to affection status.

PubMed Disclaimer

References

    1. Am J Hum Genet. 1959 Mar;11(1):1-16 - PubMed
    1. Am J Hum Genet. 1967 Jan;19(1):23-34 - PubMed
    1. Clin Genet. 1971;2(5):303-14 - PubMed
    1. Am J Hum Genet. 1974 May;26(3):331-59 - PubMed
    1. Am J Hum Genet. 1974 Jul;26(4):489-503 - PubMed

Publication types

LinkOut - more resources