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Review
. 1994 Apr;4(2):185-95.
doi: 10.1016/s0959-437x(05)80044-9.

DNA replication: enzymology and mechanisms

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Free article
Review

DNA replication: enzymology and mechanisms

Z Kelman et al. Curr Opin Genet Dev. 1994 Apr.
Free article

Abstract

Research into the enzymology of DNA replication has seen a multitude of highly significant advances during the past year, in both prokaryotic and eukaryotic systems. The scope of this article is limited to chromosomal replicases and origins of initiation. The multiprotein chromosomal replicases of prokaryotes and eukaryotes appear to be strikingly similar in structure and function, although future work may reveal their differences. Recent developments, elaborating the activation of origins in several systems, have begun to uncover mechanisms of regulation. The enzymology of eukaryotic origins has, until now, been limited to viral systems, but over the past few years, enzymology has caught a grip on the cellular origins of yeast.

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