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. 1994;34(4):361-3.
doi: 10.1007/BF00686046.

Response rates--an evolution

E Poplin  1 , L Baker
Affiliations

Response rates--an evolution

E Poplin et al. Cancer Chemother Pharmacol. 1994.

Abstract

The documented frequency of response of cancers to common chemotherapy agents and combinations appears to have decreased over the decades. Multiple reasons exist for this decline including: changes in eligibility and evaluability criteria; changes in the type of patients entered onto trial; and, altered criteria for response and methods for response assessment. The disinclination to publish negative results also permits a bias in a favor of overestimating a drug's efficacy. Circumspection now is advised in assessing data from older trials.

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References

    1. J Natl Cancer Inst. 1991 Jul 3;83(13):926-32 - PubMed
    1. Cancer. 1976 Jul;38(1):388-94 - PubMed
    1. Cancer. 1980 Sep 1;46(5):1286-90 - PubMed
    1. J Clin Oncol. 1984 Nov;2(11):1281-8 - PubMed
    1. Control Clin Trials. 1987 Dec;8(4):343-53 - PubMed

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