Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Jul 18;348(3):239-43.
doi: 10.1016/0014-5793(94)00612-1.

Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes

W Tang  1 , X C Yang
Affiliations
Free article
Comparative Study

Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes

W Tang et al. FEBS Lett. .
Free article

Abstract

We have cloned a novel inward rectifier K+ channel (hIRK2) from a human frontal cortex cDNA library. The amino acid sequence of hIRK2 shares 60% and 40% identity with the mouse IRK1 and the rat ROMK1 channels, respectively. Xenopus oocytes injected with hIRK2 cRNA showed an inwardly rectifying K+ current that had a prominent 'N-shape' I-V curve and was blocked by extracellular Ba2+. The hIRK2 channel has two unique features: (a) an 18 amino acid insertion between the first transmembrane region and the pore, and (b) restricted mRNA distribution found only in human brain and heart.

PubMed Disclaimer

Publication types

MeSH terms

Associated data

LinkOut - more resources