Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Jul;94(1):101-3.
doi: 10.1007/BF02272853.

A novel mosaic Bantu/Benin/Bantu beta s haplotype found in several African populations

I Gonçalves  1 , J Gonçalves, B Périchon, L Osório-Almeida, R Krishnamoorthy, J Lavinha
Affiliations

A novel mosaic Bantu/Benin/Bantu beta s haplotype found in several African populations

I Gonçalves et al. Hum Genet. 1994 Jul.

Abstract

In a survey of the chromosomal backgrounds associated with the sickle cell gene in Portuguese-speaking populations from Europe and Africa, a discordance between the classical haplotype and the predicted allele at the RsaI polymorphism 5' to the beta globin gene was observed in four patients. Extensive typing of the corresponding beta s chromosomes at simple polymorphic repeat motifs revealed a novel "extended" haplotype that appeared to be a mosaic of (1) a Bantu-type DNase I hypersensitive site 2 within the beta globin gene cluster locus control region, (2) a Benin 5' subhaplotype, and (3) a Bantu 3' subhaplotype. We propose two alternative schedules for the generation of yet another chromosomal background of the sickle cell gene.

PubMed Disclaimer

References

    1. Am J Hum Genet. 1986 Aug;39(2):239-44 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Mar;81(6):1771-3 - PubMed
    1. Hum Genet. 1985;69(1):1-14 - PubMed
    1. Hum Genet. 1992 May;89(3):333-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Feb;81(3):853-6 - PubMed

Publication types