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Clinical Trial
. 1994 Aug;170(2):419-24.
doi: 10.1093/infdis/170.2.419.

Paromomycin for cryptosporidiosis in AIDS: a prospective, double-blind trial

A C White Jr  1 , C L Chappell, C S Hayat, K T Kimball, T P Flanigan, R W Goodgame
Affiliations
Clinical Trial

Paromomycin for cryptosporidiosis in AIDS: a prospective, double-blind trial

A C White Jr et al. J Infect Dis. 1994 Aug.

Abstract

To test the effects of paromomycin, 10 patients with AIDS and cryptosporidiosis were randomized to paromomycin or placebo in a double-blind trial. After 14 days, patients were switched to the other treatment for 14 additional days. Measures included the number and character of each stool and weekly 24-h stool specimens for weight and oocyst excretion. During the paromomycin treatment phase, oocyst excretion decreased from 314 x 10(6) to 109 x 10(6)24 h (P < .02). Oocyst excretion increased for the 4 patients initially on placebo compared to a median decrease of 128 x 10(6)/24 h for the 6 initially treated with drug (P < .02). Stool frequency also decreased more in those treated with drug (3.6 fewer vs. 1.25 fewer/24 h, P < .05). Trends favored drug over placebo for stool weight, stool character, and Karnofsky score. Paromomycin treatment resulted in improvement in both clinical and parasitologic parameters in cryptosporidiosis in AIDS.

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Comment in

  • Anticryptosporidial activity of paromomycin.
    Cirioni O, Giacometti A, Balducci M, Drenaggi D, Del Prete MS, Scalise G. Cirioni O, et al. J Infect Dis. 1995 Oct;172(4):1169-70. doi: 10.1093/infdis/172.4.1169. J Infect Dis. 1995. PMID: 7561208 No abstract available.
  • Paromomycin for cryptosporidiosis in AIDS.
    Verdon R, Polianski J, Gaudebout C, Pocidalo JJ. Verdon R, et al. J Infect Dis. 1995 Apr;171(4):1070; author reply 1071. doi: 10.1093/infdis/171.4.1070. J Infect Dis. 1995. PMID: 7706795 No abstract available.

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