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. 1994 Jul 28;370(6487):270-5.
doi: 10.1038/370270a0.

Structure and mechanism of interleukin-1 beta converting enzyme

K P Wilson  1 , J A Black, J A Thomson, E E Kim, J P Griffith, M A Navia, M A Murcko, S P Chambers, R A Aldape, S A Raybuck, et al.
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Structure and mechanism of interleukin-1 beta converting enzyme

K P Wilson et al. Nature. .

Abstract

Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.

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