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Clinical Trial
. 1994 Jul;44(7):1309-12.
doi: 10.1212/wnl.44.7.1309.

Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

J R Brasic  1 , J Y Barnett, D Kaplan, B B Sheitman, P Aisemberg, R T Lafargue, S Kowalik, A Clark, M O Tsaltas, J G Young
Affiliations
Clinical Trial

Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

J R Brasic et al. Neurology. 1994 Jul.

Abstract

In an open, nonblind clinical trial, clomipramine reduced adventitious movements and compulsions in five previously medicated prepubertal boys with autistic disorder and severe mental retardation. Poorly adapted rating scales, interrater variability, subject heterogeneity, different treatment histories, and environmental stresses confounded the assessment of treatment effects.

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