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Case Reports
. 1994 Mar-Apr;12(2):195-7.

Three cases of arthritis after BCG therapy for bladder cancer

P Goupille  1 , J L Poet, F Jattiot, J P Mattei, V Védère, I Tonolli-Serabian, H Roux, J P Valat
Affiliations
  • PMID: 8039289
Case Reports

Three cases of arthritis after BCG therapy for bladder cancer

P Goupille et al. Clin Exp Rheumatol. 1994 Mar-Apr.

Abstract

The authors report three cases of arthritis occurring after treatment with BCG immunotherapy for bladder disease. This complication is observed in 0.5 to 1% of treated patients and affects the small joints within 1 to 5 months of the first BCG injection. The clinical outcome is favourable with non-steroidal antiinflammatory drugs. This form of arthritis may be attributable to a cross-reaction between antigenic components of cartilaginous proteoglycan and BCG, influenced by a particular HLA-DR pattern, and with the intervention of a heat shock protein.

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