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. 1975;48(2):182-91.
doi: 10.1159/000231304.

Studies on the mechanism of macrophage-mediated cytotoxicity

F G Ziegler, M L Lohmann-Matthes, H Fischer

Studies on the mechanism of macrophage-mediated cytotoxicity

F G Ziegler et al. Int Arch Allergy Appl Immunol. 1975.

Abstract

MCF is a product of sensitized T lymphocytes, which is actively synthesized and secreted when lymphocytes are incubated with the appropriate target cells. The process of macrophage activation leading to cytotoxicity needs a period of 24h. Macrophage-mediated cytotoxicity is restricted to the specific target cell. B cell antibody does not seem to be involved. The reaction cannot be inhibited by rabbit antimouse immunoglobulin. However, various conditions, which may interfere with this specificity, are discussed.

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