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. 1975 Mar;40(3):509-11.
doi: 10.1210/jcem-40-3-509.

Fasting blunts the TSH response to synthetic thyrotropin-releasing hormone (TRH)

A I Vinik, W J Kalk, H McLaren, S Hendricks, B L Pimstone

Fasting blunts the TSH response to synthetic thyrotropin-releasing hormone (TRH)

A I Vinik et al. J Clin Endocrinol Metab. 1975 Mar.

Abstract

Thyrotropin (TSH) responses to intravenous thyrotropin-releasing hormone (TRH) were studied in 9 men after 12 and 36-h fasts separated by more than a week and performed in random order. The TSH, basally and in response to TRH, was significantly lower after the 36-h fast compared to that after 12 h. The mechanism for this effect is not clear, but may be related to the altered hormonal or fuel status associated with prolonged fasting.

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