doi: 10.1093/nar/22.13.2476.
Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120
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- PMID: 8041608
- PMCID: PMC308198
- DOI: 10.1093/nar/22.13.2476
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Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120
Nucleic Acids Res.
.
Free PMC article
Abstract
Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferation-associated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.
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