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. 1993 Aug;43(8):1551-5.
doi: 10.1212/wnl.43.8.1551.

Suppression of dyskinesias in advanced Parkinson's disease. II. Increasing daily clozapine doses suppress dyskinesias and improve parkinsonism symptoms

J P Bennett Jr  1 , E R Landow, L A Schuh
Affiliations

Suppression of dyskinesias in advanced Parkinson's disease. II. Increasing daily clozapine doses suppress dyskinesias and improve parkinsonism symptoms

J P Bennett Jr et al. Neurology. 1993 Aug.

Abstract

We gave increasing daily doses of clozapine to six patients with advanced Parkinson's disease (PD) and levodopa-induced dyskinesias. Clozapine reduced the daily dyskinesia time five-fold, increased "on" time eight-fold, and doubled the serum [DOPA] producing half-maximal dyskinesia. Parkinsonism scores after overnight DOPA withdrawal improved with increasing daily clozapine intake, and there was no clozapine dose-related shift in levodopa dose response for relief of parkinsonism. Patients experienced sedation, sialorrhea, and orthostatic hypotension. Clozapine appears to be an effective agent for suppression of levodopa-induced dyskinesias in PD.

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Comment in

  • Parkinson's disease dyskinesias.
    Quinn NP. Quinn NP. Neurology. 1994 Jun;44(6):1187; author reply 1187-8. doi: 10.1212/wnl.44.6.1187-a. Neurology. 1994. PMID: 8208428 No abstract available.

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