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. 1994 Jun;5(6):365-71.
doi: 10.1007/BF00356556.

Efficient identification and regional positioning of YAC and cosmid clones to human chromosome 21 by radiation fusion hybrids

J Kumlien  1 , T Labella, G Zehetner, R Vatcheva, D Nizetic, H Lehrach
Affiliations

Efficient identification and regional positioning of YAC and cosmid clones to human chromosome 21 by radiation fusion hybrids

J Kumlien et al. Mamm Genome. 1994 Jun.

Abstract

The use of integrated mapping strategies involving bacterial, yeast, and rodent cells as hosts simplifies the construction of maps, which combine long-range order, high resolution, and easy access to the cloned DNA. Radiation-fusion hybrids offer a specially powerful long-range mapping system for human chromosomes. We describe here techniques for establishing a radiation-fusion hybrid map of Chromosome (Chr) 21q and its integration with local information on YAC and cosmid positions.

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