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. 1978 Aug;27(2):313-9.
doi: 10.1128/JVI.27.2.313-319.1978.

Induction of type C RNA virus from cultured rabbit lymphosarcoma cells

H G Bedigian, R R Fox, H Meier

Induction of type C RNA virus from cultured rabbit lymphosarcoma cells

H G Bedigian et al. J Virol. 1978 Aug.

Abstract

Type C RNA virus(es) was readily released from primary lymphosarcoma cell cultures of WH/J rabbits after induction with halogenated pyrimidines. The virus contained an RNA-directed DNA polymerase and the p30 structural protein. The rabbit virus RNA-directed DNA polymerase and p30 protein shared antigenic homologies with other mammalian type C oncornaviruses but appear to also possess unique antigenic determinants. Normal rabbit liver contained DNA homologous to a 3H-labeled complementary DNA transcript of the rabbit viral genome, indicating that type C viral genetic information is present in at least the WH/J strain of rabbits.

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References

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