[The use of Sch 1000 in inhalation treatment with intermittent positive pressure of chronic obstructive respiratory diseases (author's transl)]

Abstract

The use of the atropine derivative Sch 1000 by inhalation assisted by simultaneous intermittent positive pressure respiration was investigated in two groups of patients with moderate and severe obstruction of the respiratory tract with reference to the relationships between time and dose and effect. The maximum effect on the specific resistance (42%) was obtained after 30 minutes and persisted for about 2 hours depending on the severity of the obstruction. An attenuated effect was also still detectable after 4 hours. 50 mcg Sch 1000 was found to be an adequately effective dose. No side effects were observed on the pulse and blood pressure.