[Studies of the induction of amyloidosis by chondroitin sulfate. 2. Different distribution of amyloid after subcutaneous and intraperitoneal injection of chondroitin sulfate (author's transl)]

Abstract

Two groups of mice (A/J/Han) were treated with casein for 3 weeks. They then received chondroitin sulfate for 1 week, the one group subcutaneously and the other intraperitoneally. Intraperitoneally, chondroitin sulfate produces a more pronounced amyloidosis than subcutaneously. It also causes a marked amyloidosis of the draining lymph nodes of the abdomen. These alterations probably result from an unspecific amyloidogenic effect of chondroitin sulfate, which becomes stronger as local concentration increases.