[The clinical and hemodynamic aspects of using peripheral vasodilators in hypertension in pregnant women]

Abstract

The clinical efficacy of various vasodilators characterized by different direction of the hemodynamic action (arteriolar, mixed, venous) was assessed in therapy of the slight and medium-severe hypertensive syndrome in 92 pregnant women aged 19-36 at pregnancy terms of 24 to 39 weeks. The drugs were administered as monotherapy. Twenty-two healthy women with the normal gestation process made up the reference group. Echocardiograms have shown before the course of treatment the hyper-, hypo-, and eukinetic changes in the hemodynamics (26, 31, 35 cases, respectively). Venodilators (sustonit-mitte) were found the most effective in the pregnant women with the hyperkinetic type of circulation; in patients with the eu- and hypokinetic type both mixed vasodilators and the arteriolodilators (prazosin, cordafen) were effective. Venodilators are not recommended for patients with the hyperkinetic circulation type because of an undesirable reduction of myocardial contractility.