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. 1975 Jun 1;141(6):1261-8.
doi: 10.1084/jem.141.6.1261.

Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury

M J Polley, R L Nachman

Ultrastructural lesions on the surface of platelets associated with either blood coagulation or with antibody-mediated immune injury

M J Polley et al. J Exp Med. .

Abstract

During blood coagulation ultrastructural lesions were produced on the platelet membrane. They were dependent on the presence of both thrombin and complement (C) and were morphologically identical to the C-dependent ultrastructural lesions (type II) seen in red cells subsequent to activation of C by the alternate mechanismmthough similar in shape they differed in size from ultrastructural lesions (type I) PRODUCED BY ACTIVATION OF C via the classic mechanismmlesions of type I were seen on the platelet surface subsequent to antibody-dependent activation of the C system.

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