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. 1994 Aug 2;91(16):7598-602.
doi: 10.1073/pnas.91.16.7598.

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst

S A Duncan  1 , K Manova, W S Chen, P Hoodless, D C Weinstein, R F Bachvarova, J E Darnell Jr
Affiliations

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst

S A Duncan et al. Proc Natl Acad Sci U S A. .

Abstract

The expression of HNF-4 (hepatocyte nuclear factor 4) mRNA in postimplantation mouse embryos was analyzed by in situ hybridization. Expression was found in the primary endoderm at embryonic day 4.5 and was restricted to the columnar visceral endoderm cells of the yolk sac from day 5.5 to day 8.5. HNF-4 mRNA was first detected in embryonic tissues at day 8.5, in the liver diverticulum and the hindgut. At later times HNF-4 transcripts were observed in the mesonephric tubules, pancreas, stomach, and intestine and, still later, in the metanephric tubules of the developing kidney. This expression pattern suggests that HNF-4 has a role in the earliest stages of murine postimplantation development as well as in organogenesis.

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References

    1. Dev Biol. 1966 Jun;13(3):311-48 - PubMed
    1. Development. 1993 Nov;119(3):567-78 - PubMed
    1. J Embryol Exp Morphol. 1978 Feb;43:289-313 - PubMed
    1. Cell Differ. 1980 Oct;9(5):269-79 - PubMed
    1. J Cell Physiol. 1983 Jun;115(3):225-30 - PubMed

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