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Review
. 1994 Jun:88 Suppl 1:S31-2.
doi: 10.1016/0035-9203(94)90468-5.

The mode of action of antimalarial endoperoxides

S R Meshnick  1
Affiliations
Review

The mode of action of antimalarial endoperoxides

S R Meshnick. Trans R Soc Trop Med Hyg. 1994 Jun.

Abstract

The mechanism of action of artemisinin appears to involve two steps. In the first step, activation, intra-parasitic iron catalyses the cleavage of the endoperoxide bridge and the generation of free radicals. In the second step, alkylation, the artemisinin-derived free radical forms covalent bonds with parasite proteins.

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