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. 1975 Mar;72(3):819-23.
doi: 10.1073/pnas.72.3.819.

Variability of three-dimensional structure in immunoglobulins

E A Padlan, D R Davies

Variability of three-dimensional structure in immunoglobulins

E A Padlan et al. Proc Natl Acad Sci U S A. 1975 Mar.

Abstract

A comparison of various variable immunoglobulin domains demonstrates that structural variability parallels the observed frequency of amino-acid substitutions. The similarity of the structural frameworks is in good agreement with the evolutionary relationships of the chains as derived from sequence analysis.

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References

    1. Biochemistry. 1974 Sep 10;13(19):4033-8 - PubMed
    1. Annu Rev Biochem. 1969;38:415-66 - PubMed
    1. J Mol Biol. 1974 May 5;85(1):177-81 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3305-10 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Mar;71(3):845-8 - PubMed

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