Antibody responses to neonatal immunisation in calves

Abstract

Antibody responses were measured in colostrum-fed (CF) and colostrum-deprived (CD) calves immunised at ages varying from birth to four months using a variety of antigens with and without adjuvant. In addition immunoglobulin production in CD calves over the same period was compared with that of CF calves. A marked unresponsiveness to antigens injected at birth was observed if maternal antibody specific for the antigen used was present in the circulation. However, significant responses to all antigens tested occurred in CD calves and also in CF calves immunised with an antigen (egg albumin) to which there was no maternal antibody. Since these responses were not as great as those in older calves immunised similarly it is clear that age was influencing the response. It was also found that subsequent responsiveness was not significantly enhanced or impaired by neonatal exposure to antigen. With respect to immunoglobulin production the results conclusively demonstrated that endogenous production occurred much earlier in CD calves than CF calves and even after 128 days the serum concentrations of IgG1 and IgA in CD calves exceeded those for CF calves. Thus it appears that the most important consideration in immunological responsiveness of neonates is not so much immaturity of the lymphoid system as the effects of maternal antibody on the cells in that system.