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. 1994 Jul 15;223(2):567-74.
doi: 10.1111/j.1432-1033.1994.tb19026.x.

Role of a distal promoter element in the S-phase control of the human H1.2 histone gene transcription

A Eilers  1 , H Bouterfa, S Triebe, D Doenecke
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Free article

Role of a distal promoter element in the S-phase control of the human H1.2 histone gene transcription

A Eilers et al. Eur J Biochem. .
Free article

Abstract

The expression of one of the human main type H1 histone genes (termed H1.2) appears to be regulated by several trans-acting factors. Upstream of consensus regulatory regions, such as the TATA-, CCAAT- and H1-box (AAACACA) sequences, a crucial control site is located between nucleotide positions -536 and -412 (relative to the ATG initiation site). Removal of this promoter portion causes in chloramphenicol acetyl transferase reporter gene constructs a loss of the S-phase control function of the H1.2 promoter in HeLa cells. Electrophoretic mobility-shift assay and DNase I footprinting analysis suggest that the H1-box variant AAACAGA is a potential control element within the distal promoter region.

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