Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 May;5(1):45-50.
doi: 10.1016/0092-8674(75)90090-2.

Identification of specific crosslinked histones after treatment of chromatin with formaldehyde

F Van Lente, J F Jackson, H Weintraub

Identification of specific crosslinked histones after treatment of chromatin with formaldehyde

F Van Lente et al. Cell. 1975 May.

Abstract

Treatment of chromatin or nuclei with formaldehyde or glutaraldehyde results in the appearance of crosslinked histones as analyzed on SDS gels. The identity of two major crosslinked products was determined by iodinating the product and analzying the tryptic peptides. The results show that one product is a dimer of histones IIb2 and IIb1 and another product is a dimer of histones IIb2 and IV. These species represent no more than 15% of the total cellular histone.

PubMed Disclaimer

LinkOut - more resources