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. 1994 Sep;68(9):6087-91.
doi: 10.1128/JVI.68.9.6087-6091.1994.

The sequences of and distance between two cis-acting signals determine the efficiency of ribosomal frameshifting in human immunodeficiency virus type 1 and human T-cell leukemia virus type II in vivo

H Kollmus  1 , A Honigman, A Panet, H Hauser
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The sequences of and distance between two cis-acting signals determine the efficiency of ribosomal frameshifting in human immunodeficiency virus type 1 and human T-cell leukemia virus type II in vivo

H Kollmus et al. J Virol. 1994 Sep.

Abstract

We have analyzed in cell culture the sequence elements that control the level of ribosomal frameshifting in the human T-cell leukemia virus type II (HTLV-2) gag-pro junction. The slippery sequence of HTLV-2 is sufficient to dictate a basal level of frameshifting. This level is enhanced by its upstream sequence context and by the downstream stem-loop structure which is located at an optimal distance of 7 bases. Frameshifting in human immunodeficiency virus gag-pol is similar to that of HTLV-2 gag-pro. However, experiments using hybrid cassettes of HTLV-2 and human immunodeficiency virus type 1 frameshift elements show that while the slippery sequence of HTLV-2 is less efficient, the stem-loop structure is a more efficient enhancer.

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References

    1. J Virol. 1993 Sep;67(9):5579-84 - PubMed
    1. Cell. 1993 Jul 16;74(1):93-103 - PubMed
    1. Nucleic Acids Res. 1981 Jan 10;9(1):133-48 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 May;82(10):3101-5 - PubMed
    1. Nature. 1988 Jan 21;331(6153):280-3 - PubMed

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