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. 1994 Aug 15;202(3):1505-10.
doi: 10.1006/bbrc.1994.2101.

Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism

G Vezzoli  1 , M C Reina, D Cusi, P Casirati, L Soldati, T Azzani, R Muirhead, G Bianchi
Affiliations

Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism

G Vezzoli et al. Biochem Biophys Res Commun. .

Abstract

The chronic effect of PTH on erythrocyte membrane Ca transport was examined. (Ca+Mg)ATPase activity and passive Sr influx were measured to assess the rate of passive Ca influx (total and inhibited by dihydropyridines [DHPs]), in erythrocytes from patients with primary hyperparathyroidism and normal controls. Erythrocyte Sr influx was lower in patients, due to a decreased DHP-sensitive Sr influx. Conversely, efflux activity of (Ca+Mg)ATPase was not different in patients and controls. We hypothesize that in primary hyperparathyroidism chronic PTH stimulation may induce a downregulation of the erythrocyte Ca influx mediated by DHP-sensitive Ca carrier.

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