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. 1994 Aug 15;350(1):139-42.
doi: 10.1016/0014-5793(94)00755-1.

Iron deprivation-induced apoptosis in HL-60 cells

K Fukuchi  1 , S Tomoyasu, N Tsuruoka, K Gomi
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Free article

Iron deprivation-induced apoptosis in HL-60 cells

K Fukuchi et al. FEBS Lett. .
Free article

Abstract

Iron deprivation of HL-60 cells with deferoxamine B mesylate (DFO) induced apoptosis. DNA fragmentation became apparent with 10(-6) M DFO after 48 h treatment. The apoptosis peak according to the DNA histogram on flow cytometry and typical nuclear collapse and were observed microscopically after 48 h treatment with 10(-4) M DFO. Cells treated with 10(-4) M DFO for as little as 24 h were shown to be committed to apoptosis, as chromatin condensation progressed gradually thereafter.

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