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. 1994 Aug 15;350(1):77-81.
doi: 10.1016/0014-5793(94)00737-3.

Carboxyl-terminal truncation of apolipoproteinB-100 inhibits lipoprotein(a) particle formation

B Gabel  1 , Z Yao, R S McLeod, S G Young, M L Koschinsky
Affiliations
Free article

Carboxyl-terminal truncation of apolipoproteinB-100 inhibits lipoprotein(a) particle formation

B Gabel et al. FEBS Lett. .
Free article

Abstract

Recombinant expression systems for both apo(a) and apoB were used to identify sequences in apoB which are required for Lp(a) formation. Incubation of a [35S]Cys-labelled 17-kringle form of apo(a) with supernatants from rat hepatoma (McA-RH7777) cells expressing apoB-88, apoB-94 and apoB-100 resulted in covalent r-Lp(a) formation only with apoB-100. Additionally, apoB-86 present in the LDL of a hypobetalipoproteinemic subject did not associate with a 12-kringle form of recombinant apo(a) to form r-Lp(a) complexes. Our data suggest that sequences within the C-terminal 6% of apoB-100 are essential for Lp(a) assembly.

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