[The evaluation of the analgesic and anti-inflammatory effects of flurbiprofen mouthwash and 100-mg tablets in oral medicine]

Abstract

In stomatology, the use of non-steroidal anti-inflammatory drugs is very frequently reported in case of essential algia, of infections and in post-surgery prevention. In this open controlled study, efficacy and tolerability of two different formulations of a non steroidal anti-inflammatory drug were evaluated in patients requiring extraction of inferior VI molar (limb gingivectomy and osteotomy using a rotatory instrument in molar roots). 40 patients following a randomisation list, were allocated to two balanced groups. In both oral standardised antibiotic therapy was administered and the first group received 1 tablet of flurbiprofen 100 mg twice daily, the second received flurbiprofen mouth wash 10 ml (0.25%) rinsing their mouths 6 times daily for three minutes. The anti-inflammatory and antibiotic treatment started one day before the extraction and lasted for the following three days. Pain symptoms, post-operative edema and healing of the surgical wound were observed. The profile of intensity of pain was similar in the two groups, but improved more rapidly in the group receiving oral flurbiprofen, although the recovery from the edema was achieved quicker with the mouth wash rinses, as well as the healing of the wound. Tolerability was good for both the formulations, in fact no patients stopped the therapy because of adverse events.