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Comparative Study
. 1994 May;38(5):1169-71.
doi: 10.1128/AAC.38.5.1169.

In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum

L K Basco  1 , S Mitaku, A L Skaltsounis, N Ravelomanantsoa, F Tillequin, M Koch, J Le Bras
Affiliations
Comparative Study

In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum

L K Basco et al. Antimicrob Agents Chemother. 1994 May.

Abstract

The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.

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