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. 1994 May;38(5):1203-4.
doi: 10.1128/AAC.38.5.1203.

Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever

B J Currie  1 , T Burt, E L Kaplan
Affiliations

Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever

B J Currie et al. Antimicrob Agents Chemother. 1994 May.

Abstract

Plasma penicillin levels were studied 2, 3, and 4 weeks after intramuscular benzathine penicillin G (BPG) doses of 1,200,000, 1,800,000, and 2,400,000 U. Proportions of patients with penicillin levels above 25 ng/ml at each week increased with increasing BPG dose. Further studies of higher-dose BPG for rheumatic fever prophylaxis are required.

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