Thickening of the heel-pad associated with long-term Dilantin therapy
- PMID: 807118
- DOI: 10.2214/ajr.124.1.52
Thickening of the heel-pad associated with long-term Dilantin therapy
Abstract
Thickening of the heel-pad is added to the list of side effects of Dilantin medication. Any measurement above 20 mm. in a white patient was considered abnormal. Only 1 of 43 controls measured above this value, while in patients receiving Dilantin the percentage of patients manifesting abnormally thickened hell-pads increased steadily with length of treatment; after 10 years 7 out of 12 patients showed this change. Dilantin medication should be included in the differential diagnosis of heel-pad thickening.
Similar articles
-
Calvarial thickening after Dilantin medication.Am J Roentgenol Radium Ther Nucl Med. 1970 Sep;110(1):102-5. doi: 10.2214/ajr.110.1.102. Am J Roentgenol Radium Ther Nucl Med. 1970. PMID: 5459522 No abstract available.
-
Heel pad thickness: determination by high-resolution ultrasonography.J Ultrasound Med. 1985 Apr;4(4):173-4. doi: 10.7863/jum.1985.4.4.173. J Ultrasound Med. 1985. PMID: 3886923
-
Heel Pad Stiffness in Plantar Heel Pain by Shear Wave Elastography.Ultrasound Med Biol. 2015 Nov;41(11):2890-8. doi: 10.1016/j.ultrasmedbio.2015.07.004. Epub 2015 Aug 20. Ultrasound Med Biol. 2015. PMID: 26299685
-
Dilantin jeopardy: avoiding the dangers of phenytoin.Medsurg Nurs. 1998 Dec;7(6):343-7, 356. Medsurg Nurs. 1998. PMID: 10036438 Review.
-
MR Imaging Findings in Heel Pain.Magn Reson Imaging Clin N Am. 2017 Feb;25(1):79-93. doi: 10.1016/j.mric.2016.08.011. Magn Reson Imaging Clin N Am. 2017. PMID: 27888853 Review.
Cited by
-
Phenytoin-induced DNA synthesis and inositol 1,4,5-trisphosphate formation in L-929 fibroblasts.Experientia. 1991 Jul 15;47(7):728-30. doi: 10.1007/BF01958828. Experientia. 1991. PMID: 2065771
-
Anticonvulsant drugs. An update.Drugs. 1984 Apr;27(4):328-63. doi: 10.2165/00003495-198427040-00003. Drugs. 1984. PMID: 6327221 Review.
-
The risk-benefit ratio of anticonvulsant drugs.Med Toxicol Adverse Drug Exp. 1987 Sep-Oct;2(5):324-37. doi: 10.1007/BF03259952. Med Toxicol Adverse Drug Exp. 1987. PMID: 3312929 Review.
-
Low dose phenytoin is an osteogenic agent in the rat.Calcif Tissue Int. 1995 Jan;56(1):42-8. doi: 10.1007/BF00298743. Calcif Tissue Int. 1995. PMID: 7796345
-
Phenytoin and fluoride act in concert to stimulate bone formation and to increase bone volume in adult male rats.Calcif Tissue Int. 1995 May;56(5):390-7. doi: 10.1007/BF00301608. Calcif Tissue Int. 1995. PMID: 7621347