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Case Reports
. 1994 Aug;76(1):70-1.
doi: 10.1016/0165-4608(94)90075-2.

Loss of Y chromosome. An age-related event or a cytogenetic marker of a malignant clone?

D Abeliovich  1 , O Yehuda, S Ben-Neriah, R Or
Affiliations
Case Reports

Loss of Y chromosome. An age-related event or a cytogenetic marker of a malignant clone?

D Abeliovich et al. Cancer Genet Cytogenet. 1994 Aug.

Abstract

Cytogenetic analysis of bone marrow cells performed at the time of diagnosis of ALL in an 80-year-old male patient revealed two unrelated abnormal clones. One included the 9;22 translocation (Philadelphia chromosome) as the sole aberration and the second was missing the Y chromosome. The significance of this finding in the light of the role of -Y clone in malignancy is discussed.

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