doi: 10.1099/00221287-88-2-289.
Properties of some norvaline-resistant mutants of Bacillus subtilis
- PMID: 807681
- DOI: 10.1099/00221287-88-2-289
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Properties of some norvaline-resistant mutants of Bacillus subtilis
J Gen Microbiol.
1975 Jun.
Abstract
DL-Norvaline inhibits growth of wild-type Bacillus subtilis. A number of mutants resistant to growth inhibition by this analogue were isolated and studied. Cross-feeding experiments and paper chromatography of culture supernatants indicated that the mutants excreted leucine and possibly valine and glutamate. Enzymic analysis indicated that the mutants were derepressed for acetohydroxy-acid synthetase and alpha-isopropylmalate synthetase; however, no derepression of threonine deaminase, dihydroxyacid dehydrase or transaminase B was observed.
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