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Review
. 1994 Aug 30;91(18):8307-13.
doi: 10.1073/pnas.91.18.8307.

Increasing complexity of the dystrophin-associated protein complex

J M Tinsley  1 , D J Blake, R A Zuellig, K E Davies
Affiliations
Review

Increasing complexity of the dystrophin-associated protein complex

J M Tinsley et al. Proc Natl Acad Sci U S A. .

Abstract

Duchenne muscular dystrophy is a severe X chromosome-linked, muscle-wasting disease caused by lack of the protein dystrophin. The exact function of dystrophin remains to be determined. However, analysis of its interaction with a large oligomeric protein complex at the sarcolemma and the identification of a structurally related protein, utrophin, is leading to the characterization of candidate genes for other neuromuscular disorders.

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References

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