[Tubulization in the reconstruction of the peripheral nervous system: the current status of experimentation]

Abstract

The interest in developing a prosthesis that may be effective in nerve repair as an alternative to autologous grafts, promotes experimental investigations in order to improve the so called tubulization techniques. A review of the literature of the last 10 years is performed to draw an outline of the state of the research, pointing out three main topics: the animal model, the type of the conduit and the length of the repaired gap. The rat, the rabbit and non human primates are the species with which experimental models are most often fashioned for this purpose. Among the great number of investigated conduits, interesting perspectives are arrived at mainly by those obtained with biologic or degradable materials; until now, experimental nerve defects of 3 cm or less are better repaired with artificial guides while unsatisfactory results were reported for the repair of longer gaps. The introduction in the micro-environment of the conduit of neurotrophic substances represents a challenge for the future development of these investigations aimed at improving healing and obtaining nerve regeneration through extensive defects.