Typhoid gamma G, gamma M and gamma A antibodies in persons with different relation to the typhoid infection

Abstract

A study has been made of the differences in specific antibodies in three classes of immunoglobulins in sera of persons with different relation to the typhoid infection. The amount of specific antibodies was calculated from the differences in the levels of serum IgG, IgM and IgA before and after absorption with purified O, Vi and H antigens. The concentration of each immunoglobulin class was determined by means of single radial immunodiffusion. The results showed a significant decrease of IgA in the sera of typhoid carriers and IgM in the sera of patients with typhoid fever and persons with typhoid history after the absorption with the above mentioned antigens. The amount of eliminated antibodies in IgA class of the sera from typhoid carriers was 2.4 time higher as compared with the sera of non-carriers with typhoid history. The level of gamma M antibodies was 2.2 time higher in the sera of patients with typhoid fever and 2.8 time higher in the sera of persons with typhoid history than in the sera of typhoid carriers. In the IgG class no significant differences were observed.