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Review
. 1994 Sep;56(3):416-22.
doi: 10.1002/jlb.56.3.416.

Brain macrophages: neurotoxic or neurotrophic effector cells?

M Mallat  1 , B Chamak
Affiliations
Review

Brain macrophages: neurotoxic or neurotrophic effector cells?

M Mallat et al. J Leukoc Biol. 1994 Sep.

Abstract

The development of the central nervous system and various pathological contexts imply remodeling or alteration of neuronal networks associated with tissue recruitment of mononuclear phagocytes. Purification and culture of brain macrophages have provided a tool for investigating the functions of these cells. We discuss different mechanisms whereby macrophages could directly influence the survival of neurons and the growth of their processes.

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