doi: 10.1016/0304-3940(94)90638-6.
Regulation of Ca2+ concentration by second messengers in newt olfactory receptor cell
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- PMID: 8084489
- DOI: 10.1016/0304-3940(94)90638-6
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Regulation of Ca2+ concentration by second messengers in newt olfactory receptor cell
Neurosci Lett.
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Abstract
The role of IP3 in olfactory transduction is controversial. This issue was addressed by measuring intracellular Ca2+ concentration under voltage clamp in newt olfactory receptor cells. Odorant stimulation and dialysis of cells with cyclic AMP (cAMP) caused an increase in intracellular Ca2+ concentration that originated in the cilia, as expected from previous works. However, dialysis with IP3 caused a slower rise in Ca2+ concentration that originated in the cell body. Our results suggest that IP3 influences transduction by regulating the intracellular Ca2+ concentration, rather than by carrying the transduction current.
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