Review
doi: 10.1016/0264-410x(94)90259-3.
Toxin inactivation and antigen stabilization: two different uses of formaldehyde
Affiliations
- PMID: 8085372
- DOI: 10.1016/0264-410x(94)90259-3
Item in Clipboard
Review
Toxin inactivation and antigen stabilization: two different uses of formaldehyde
Vaccine.
1994 May.
Abstract
Since the 1920s, when Ramon discovered the detoxifying properties of formaldehyde, this compound has been used to inactivate toxins, whole bacterial cells and viruses. With the development of vaccines that are detoxified by genetic manipulation, formaldehyde has a new role as a stabilizer of such genetically detoxified antigens.
Comment in
-
Formaldehyde as an inactivant.Vaccine. 1995 Feb;13(2):231. doi: 10.1016/0264-410x(95)93142-v. Vaccine. 1995. PMID: 7625122 No abstract available.
Similar articles
-
The reaction of bacterial toxins with formaldehyde and its use for antigen stabilization.Dev Biol Stand. 1996;87:125-34. Dev Biol Stand. 1996. PMID: 8854009
-
Detection of stable epitopes on formaldehyde-detoxified Pasteurella multocida toxin by monoclonal antibodies.Vaccine. 1991 Nov;9(11):817-24. doi: 10.1016/0264-410x(91)90219-v. Vaccine. 1991. PMID: 1722064
-
[A study of the kinetics of detoxication of purified type A botulinum toxin by formalin].Biokhimiia. 1961 Jul-Aug;26:667-72. Biokhimiia. 1961. PMID: 13780379 Russian. No abstract available.
-
Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine.Vaccine. 1990 Aug;8(4):299-303. doi: 10.1016/0264-410x(90)90083-x. Vaccine. 1990. PMID: 2204242 Free PMC article. Review.
-
Development and clinical testing of an acellular pertussis vaccine containing genetically detoxified pertussis toxin.Immunobiology. 1992 Feb;184(2-3):230-9. doi: 10.1016/S0171-2985(11)80477-8. Immunobiology. 1992. PMID: 1587545 Review.
Cited by
-
Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens.NPJ Vaccines. 2023 Jul 13;8(1):101. doi: 10.1038/s41541-023-00696-w. NPJ Vaccines. 2023. PMID: 37443366 Free PMC article.
-
Development of a next-generation chikungunya virus vaccine based on the HydroVax platform.PLoS Pathog. 2022 Jul 5;18(7):e1010695. doi: 10.1371/journal.ppat.1010695. eCollection 2022 Jul. PLoS Pathog. 2022. PMID: 35788221 Free PMC article.
-
Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens.J Virol. 2015 Oct 28;90(2):813-28. doi: 10.1128/JVI.01942-15. Print 2016 Jan 15. J Virol. 2015. PMID: 26512083 Free PMC article.
-
Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.PLoS Pathog. 2018 May 10;14(5):e1006986. doi: 10.1371/journal.ppat.1006986. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29746590 Free PMC article.
-
Structure-guided antigen engineering yields pneumolysin mutants suitable for vaccination against pneumococcal disease.J Biol Chem. 2011 Apr 8;286(14):12133-40. doi: 10.1074/jbc.M110.191148. Epub 2011 Feb 4. J Biol Chem. 2011. PMID: 21296887 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
