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Review
. 1994 May;12(7):579-81.
doi: 10.1016/0264-410x(94)90259-3.

Toxin inactivation and antigen stabilization: two different uses of formaldehyde

R Rappuoli  1
Affiliations
Review

Toxin inactivation and antigen stabilization: two different uses of formaldehyde

R Rappuoli. Vaccine. 1994 May.

Abstract

Since the 1920s, when Ramon discovered the detoxifying properties of formaldehyde, this compound has been used to inactivate toxins, whole bacterial cells and viruses. With the development of vaccines that are detoxified by genetic manipulation, formaldehyde has a new role as a stabilizer of such genetically detoxified antigens.

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Comment in

  • Formaldehyde as an inactivant.
    Brown F. Brown F. Vaccine. 1995 Feb;13(2):231. doi: 10.1016/0264-410x(95)93142-v. Vaccine. 1995. PMID: 7625122 No abstract available.

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