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Clinical Trial
. 1994:396:86-90.
doi: 10.1111/j.1651-2227.1994.tb13253.x.

Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins

C Fast  1 , H Rosegger
Affiliations
Clinical Trial

Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins

C Fast et al. Acta Paediatr Suppl. 1994.

Abstract

We conducted a prospective randomized trial to compare the efficacy of oral gentamicin versus oral IgA-IgG for the prophylaxis of necrotizing enterocolitis (NEC); 200 newborns considered at high risk for NEC were assigned to group A (oral IgA-IgG, n = 100) or group B (oral Gentamicin, n = 100). NEC was diagnosed in 13 cases in group A and in 1 case in group B between the 3rd and 16th days of life. Surgical treatment was necessary in 3 cases (2 in group A). All infants survived. We conclude that oral gentamicin is more effective than oral IgA-IgG in the prevention of NEC in infants at high risk.

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Comment in

  • Necrotizing enterocolitis prophylaxis.
    Grylack L, Scanlon JW. Grylack L, et al. Acta Paediatr. 1995 Jan;84(1):21. doi: 10.1111/j.1651-2227.1995.tb13478.x. Acta Paediatr. 1995. PMID: 7734893 No abstract available.

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