Esophageal cancer, early disease: diagnosis and current treatment

Abstract

Most esophageal cancers are at a fairly advanced stage at the time of diagnosis, and curative therapy is not possible. For those that are detected early, cure may be possible, particularly if there is no lymphatic spread. Radical therapeutic approaches result in increased treatment-related mortality, high treatment-induced morbidity, and reduced quality of life. Therefore it is one of the major targets in the treatment of esophageal cancers to classify the tumor and to perform adequate stage-related therapy. The modern diagnostic procedures, such as endoscopy, endoluminal sonography, computed tomography (CT) scanning, and endoscopic biopsy, have led to major advances in preoperative staging. Endoluminal sonography is able to predict the depth of tumor infiltration in the esophageal wall and the existence of local lymph node metastasis, whereas CT scanning demonstrates distant metastasis. Histologic classification of the tumor together with genetic and cell biologic characteristics can predict the prognosis. Currently, the best prospect for cure of early esophageal cancer is surgical resection through the abdominothoracic approach, although less radical surgical procedures such as transhiatal resection without extensive lymph node dissection seem to achieve the same results. Even less traumatic is the use of minimal invasive techniques, which certainly will be used more often in the future. For early esophageal cancers limited to the epithelium and the lamina propria, local destruction of the tumor leads to long-term survival and cure. Techniques such as endoscopic resection, laser coagulation, photo-dynamic laser activation, and argon beam exposure have been described and seem to achieve similar results.(ABSTRACT TRUNCATED AT 250 WORDS)