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. 1975 Jul 21;281(2-3):211-4.

Perturbations of the levels of hypophyseal serotonin induced by oral administration of a single dose of 7, 12-dimethyl 1-2 benz(a)anthracene in rats

F Guerinot, P Janiaud, M Le Maout, C Aubert, C Bohuon
  • PMID: 809206

Perturbations of the levels of hypophyseal serotonin induced by oral administration of a single dose of 7, 12-dimethyl 1-2 benz(a)anthracene in rats

F Guerinot et al. C R Acad Hebd Seances Acad Sci D. .

Abstract

Pituitary serotonin was estimated by fluorescence technique in rats fed with DMBA at 30 days, 60 days or 90 days age. In the rats most receptive to this carcinogen, serotonin was found to be decreased to 40% of control values, for the 8 days period studied. A possible mechanism leading to hormonal unbalance is proposed.

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