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. 1994 Sep 1;302 ( Pt 2)(Pt 2):535-8.
doi: 10.1042/bj3020535.

Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus

J Alvarez-Bravo  1 , S Kurata, S Natori
Affiliations

Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus

J Alvarez-Bravo et al. Biochem J. .

Abstract

Previously, we identified a core undecapeptide of sapecin B having antimicrobial activity. Based on the structure of this peptide, we systematically synthesized peptides consisting of terminal basic motifs and internal oligo-leucine sequences and examined their antimicrobial activities. Of these peptides, RLKLLLLLRLK-NH2 and KLKLLLLLKLK-NH2 were found to have potent microbicidal activity against Staphylococcus aureus, Escherichia coli, methicillin-resistant S. aureus and Candida albicans in liquid medium. We also synthesized the D-enantiomer of KLKLLLLLKLK-NH2. This enantiomer was resistant to tryptic digestion and persisted longer in the culture medium, showing greater antimicrobial activity than the original peptide.

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