Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Feb 13;341(8842):407-8.
doi: 10.1016/0140-6736(93)92993-4.

Pregnancy and fetal long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency

B Wilcken  1 , K C Leung, J Hammond, R Kamath, J V Leonard
Affiliations

Pregnancy and fetal long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency

B Wilcken et al. Lancet. .

Abstract

We report on eleven pregnancies in 5 mothers. 6 of the babies had long-chain 3-hydroxyacyl coenzyme A dehydrogenase (LCHAD) deficiency, and each of the pregnancies was complicated by features such as fatty liver and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome. By contrast, 3 of the mothers also gave birth to unaffected babies, and these pregnancies were largely uncomplicated. We conclude that there may be adverse effects on maternal liver function from a fetus with LCHAD deficiency. Heterozygosity in the mother cannot alone account for the adverse effects because of the segregation of these effects with fetal LCHAD status.

PubMed Disclaimer

Substances