Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1993 Feb;67(2):244-6.
doi: 10.1038/bjc.1993.47.

Infrequent chromosome allele loss in fibrolamellar carcinoma

S F Ding  1 , J D Delhanty, L Bowles, J S Dooley, C B Wood, N A Habib
Affiliations
Free PMC article
Comparative Study

Infrequent chromosome allele loss in fibrolamellar carcinoma

S F Ding et al. Br J Cancer. 1993 Feb.
Free PMC article

Abstract

As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambda MS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses.

PubMed Disclaimer

References

    1. Cancer. 1980 Jul 15;46(2):372-9 - PubMed
    1. Br J Cancer. 1992 Jun;65(6):809-12 - PubMed
    1. Science. 1989 Apr 14;244(4901):207-11 - PubMed
    1. Jpn J Cancer Res. 1990 Feb;81(2):108-11 - PubMed
    1. Cancer Res. 1991 Jan 1;51(1):89-93 - PubMed

Publication types