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Case Reports
. 1993 Mar 1;71(5):1797-800.
doi: 10.1002/1097-0142(19930301)71:5<1797::aid-cncr2820710514>3.0.co;2-b.

Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer

B C Pestalozzi  1 , G A Sotos, P L Choyke, J S Fisherman, K H Cowan, J A O'Shaughnessy
Affiliations
Case Reports

Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer

B C Pestalozzi et al. Cancer. .

Abstract

Background: Typhlitis is being recognized with increasing frequency as a serious complication of aggressive chemotherapy for hematologic and solid malignancies.

Methods: In this report the authors describe two cases of typhlitis in patients with metastatic breast cancer treated with taxol and doxorubicin.

Results: Both cases occurred during the first cycle of treatment with taxol (180 mg/m2) and doxorubicin (75 mg/m2), being given simultaneously as 72-hour continuous intravenous infusions.

Conclusion: Two cases of typhlitis have occurred after combined treatment with taxol and doxorubicin, while typhlitis has not been described after treatment with either drug alone.

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